Background: Stress is a negative emotional, cognitive, behavioral and physiological process occurs as individual adjusts with stressors. Stress-induced eating may be one of the factors that leads to obesity due to increased calorie intake, associated with excess cortisol secretion. Present study aimed to assess the level of perceived stress and its association with BMI in health professional beginners. The objectives were to assess the level of stress by pre-validated perceived stress scale and the relationship between stress and obesity in first year health professional students. Material and Methods: A cross sectional study was conducted in the Department of Biochemistry, SBKS MI & RC, SVDU for consecutive two batches 2016-17 & 2017-18. Total 506 first year MBBS, BDS & BPT students were studied for age, gender and demographic parameters as weight, height & BMI. Stress was assessed by PSS-10 scale. Two groups were identified as their PSS score, stressed and non-stressed. Results: PSS score showed that among all participants 71.74% (N=363) students were stressed and 28.26% (N=143) students were non stressed. Out of 506 students 151 (approx 30%) students were having above normal BMI. BMI & PSS score showed significant association (X2, p <0.05). PSS score found to be significantly more when compared for overweight and obese categories than Normal and underweight. Conclusion: The significant association between stress level and increasing BMI shows that prompt measures should be taken to control obesity in young health professionals to control the stress and anxiety also to prevent the occurrence of life‑threatening diseases such as diabetes and hypertension.