Holoprosencephaly (HPE) is a developmental disorder. It’s a rare congenital and the most common human forebrain malformation, occurs in 1 in 250 fetuses and 1 in 16,000 live births. Occurring due to incomplete cleavage of the prosencephalon. It is seen between the 18th and the 28th day of gestation. It is affecting face and forebrain and is associated with multiple midline facial anomalies. Herewith we report an antenatal case of such patient. Patient was evaluated and because of the lethal anomalous fetus, induction was done which led to a stillborn baby. The focus of this article will be on the pathophysiology of findings visible in fetal manifestation of the HPE spectrum.