Herbal remedies used traditionally to cure different types of human disease. The research in herbal drugs, to discover single compound used a lead for developing new therapeutically active products. Cleome viscosa Linn. (wild or dog mustard), belongs to family(Capparaceae). Cleome viscosa well known plant for their antimicrobial, anti-diarrheal, hepatoprotective, analgesic and anti-fibrolytic potential. In living beings, infection caused by helminths (helminthiasis) is a severe problem to health that results in hardship and stunted growth. In the developing world, helminthiasis (in human intestine) is the most common infectious disease. The seed contained salicylic acid and Lupeol. This study has been carried out to evaluate anthelmintic potential of Cleome viscose seed by molecular docking via drug-tubulin interaction. The molecular docking result revealed that salicylic acid and Lupeol showed encouraging docking score. The docking score found to be -1.98 and -3.82 kcal mol–1 respectively.