Class II division 2 malocclusion is an obvious category of Class II malocclusion with typical characteristics like retroclined maxillary incisors and severe deep over bite, caused by both skeletal and dentoalveolar factors. In fact, diagnosing class II division 2 maloclusion is quite simple; neverthless the treatment process and prognosis are complex and delicate. This case report illustrates a combined orthodontic-orthognathic surgical treatment of a 19-year-old female with permanent dentition, sagittal skeletal Class II pattern, hypodivergent facial type and both class II molar and canine relationship with class II division 2 incisor relationship. The treatment plan was divided into 3 consecutive phases: the dentoalveolar decompensation, which lasted 13 months, the surgery of mandibular advancement and the finishing stage. The treatment had successfully improved the smile arc, the masticatory functions, and the dental occlusion of the patient.