Background: Cancer diagnosis can have an extensive impact on mental health and comfort. Depression and anxiety may hamper cancer treatment and recovery, as well as quality of life and survival. Cancer is an important incident in one's life which has substantial outcomes for patients and their families as well. The major psychological significance in cancer patients is depression that often takes less attention. Objective: The objective was to determine the prevalence of anxiety and depression among cancer patients and whether these conditions were associated with certain sociodemographic factors. Methods: It was a cross-sectional study. By convenient sampling technique, a total of 150 samples were selected. The patients were studied after histopathological confirmation of diagnosis of cancer. Sociodemographic and other data was collected by face-to-face interview using semi structured questionnaire. Data analysis was done by Statistical Package for Social Sciences (SPSS) version 26.0 and results were presented with appropriate graphs and texts. Results: The mean age was 46.5±9.5 years. 65.3% were male and 34.7% respondents were female. Male: female ratio 1.9:1. Moderate depression was higher in-service holder 53.8%. Among agriculture worker, 38.6% had mild depression symptom, within house wife 63.2% had mild to moderate depression symptom. No significant relation was found occupation with depression symptom (p>0.05). While moderate anxiety symptom was higher in-service holder 42.3%. Among agriculture worker, maximum 54.5% had moderate to severe anxiety symptom, within house wife 47.4% had moderate to severe anxiety symptom. No significant relation was found occupation with anxiety symptom also (p>0.05). Significant relation was found among income group with level of depression and anxiety symptom (p<0.05) as study showed both depression and anxiety were found more among higher income group population than lower income population. Conclusion: In this study both higher education and higher socioeconomic status were found to be predictors of depression and anxiety.