Dengue fever is the most common Arboviral disease in India. Dengue is endemic in almost all states and leading cause of hospitalization in India. An overview on Dengue burden, prevalence, Geographical distribution and seasonal trends at a particular area is necessary for administration of appropriate preventive and control measures. The present study was aimed to assess the prevalence of dengue infection among the patients suffering from acute febrile illness at GGH Mahabubnagar. A total number of 3076 clinically suspected cases of dengue were included in the study. Serum samples from these patients were collected and were subjected either dengue IgM or NS1 ELISA based on the duration of fever. Out of 3076 cases 206 were positive for dengue serology, out of them 112 were positive by NS1 ELISA and 94 were positive by IgM ELISA. In the present study commonly effected age group is 0-20yrs and showing male preponderance. Dengue infection is common in post monsoon season from September to November months. These epidemiological details in the particular region will help in proper planning of resources in disease prevention and control.