Chronic renal failure is increasingly health problem all around the world with a high burden of mortality and cardio vascular morbidity rate. The study is mainly directed to establish lipid profile in chronic renal failure by ascertaining the levels of serum cholesterol, HDL cholesterol, LDL cholesterol, VLDL cholesterol and triglycerides. In view of this extensive work has been done in the field and incessant efforts are being made to widen the horizon of lipid in chronic renal failure. The present study was aimed to find lipid abnormalities in chronic renal failure. There is significant rise in Triglycerides, VLDL, LDL in chronic renal failure. There is decrease in HDL concentration in chronic renal failure as compared to control. Increased concentration of Triglycerides and VLDL are the main causes for increased incidence of cardiovascular abnormalities in chronic renal failure.