Acute pancreatitis is the acute inflammation of the pancreas. It can be resulted due to many causes. Acute pancreatitis due to non-steroidal anti-inflammatory drugs is not commonly observed in the clinical practice. Etoricoxib is a type of non-steroidal anti-inflammatory drugs which belongs to the group of selective cyclooxygenase two enzyme inhibitors. Etoricoxib induced severe acute pancreatitis is not reported in literature. Here we describe a patient with severe acute pancreatitis caused by etoricoxib. The improvement of symptomatology and the biochemical profile was remarkable after the omission of etoricoxib. This case highlights the importance of considering etoricoxib as a cause of acute pancreatitis which needs further exploration.