Traumatic Brain Injury (TBI) is commonly associated with other injuries such as cervical spine injury (CSI) which critically affects TBI patients, interfering with airway management techniques, selection of proper radiological studies, and the management approach of both the TBI and the CSI. This study aims to assess the prevalence, etiology, and characteristics of CSI in patients who sustained TBI. Also, we will investigate other associated injuries in patients experienced combined TBI and CSI, and their effects on patients’ mortality and course of hospitalization. The study was conducted in the health information management (HIM) department. The charts of all adult (>14 years old) patients with TBI presenting to the emergency department (ED) at King Abdulaziz Medical City in Jeddah or referred from other hospital over a four years period (January 2013 to December 2016) were reviewed. 220 patients with traumatic brain injury were included in the study. Most of the patients were young adult (median age 29 years). In 185 of the 220 patients (84.1%), a diagnosis of cervical spine injury was ruled out on the basis of the clinical presentation and computed tomography scans reports. in the remaining 35 patients, cervical spine injury was confirmed with the prevalence of 15.9%. The rate of cervical spine injury was highest among young adult (men greater than women) who sustained motor vehicle related injury, and usually associated with thoracic, thoracolumbar trauma and abdominal injury that only explained by mechanism of injury.