Nerve conduction study (NCS) measures how quickly electrical signals move through peripheral nerve. It is used to assess peripheral nerve dysfunction thus diagnose the types of neuropathy, and nerve damage. The purpose of this study was to observe the significance of recording nerve conduction parameters (NCP) of common peroneal nerve (CPN) from tibialis anterior (TA) muscle in neuropathic subjects. This study included 153 subjects which were grouped, on the basis of clinical and routine NCS in to normal healthy subjects and neuropathic patients; axonal and demyelinating types. Nerve conduction parameters were recorded and analyzed by using Digital EMG machine. After categorizing the subjects, the recordings of NCP were also obtained from TA muscle on stimulation of CPN, above and below the head of fibula. Study was performed at recommended temperature (32-340C). For statistics, the data was analyzed using MS Excel 2010 and Graph pad Prism6. A t-test was applied to see the significance of NCP recorded from TA and compared it with the NCP obtained from extensor digitorum brevis (EDB) muscle in different categories of selected subjects. P-values < 0.5 were considered significant. The comparison of most NCP between TA and EDB was highly significant in these categories of selected subjects. In neuropathic patients, more than 40% were non responsive to EDB stimulation while recording from TA was comparatively convincing. Findings of the study showed that the recording of nerve conduction parameters from TA is very useful in severe neuropathic condition, therefore, should be performed routinely in nerve conduction study