The voluntary religious undertaking of fasting has attracted scientific, religious and popular interest due to its supposed health benefits. The objective of this study was to determine the effects of intermittent fasting on such parameters as body weight, blood glucose, uric acid and blood lipid profile among healthy volunteers.Seventy-five consenting Muslim medical students resident in the medical students’ hostel of the College of Medical Sciences, University of Maiduguri, Nigeria were recruited during the month of Ramadan 1428AH corresponding to September 2007. Anthropometric measurements and biochemical indices including plasma glucose, triglyceride (TG), cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL) and uric acid were evaluated a week before, three weeks into and a month after Ramadan.BMI showed significant difference in all subjects during and after Ramadan fasting, however the body weight and BMI parameters were insignificant in gender analysis. We also recorded no overall changes in total cholesterol, TG and LDL during Ramadan. However, significant increase in HDL and a slight increase in plasma glucose levels were noted during Ramadan. Further, there weresignificant increases in TG level during Ramadan and in both TG and total cholesterol after Ramadan in females. However, the atherogenic index decreased in males. BMI, total cholesterol, LDL, uric acid and atherogenic index were all decreased in overweight subjects.Females demonstrated increases in TG before Ramadan and in both TG and total cholesterol after Ramadan. Differences in the levels of physical activity, eating pattern and the fact that not all females completed the Ramadan fasting may be responsible for this observation