Abstract: The prevalence of lifestyle diseases or the Non-Communicable Diseases (NCDs) are on the rise colossally as well as globally. The key contributors are understood to be the pollutants and contaminants present in local ambient environment that trigger the onset of cellular oxidative stress i.e. imbalance in levels of oxidants and antioxidants at cell level, and the pro-inflammatory changes. Reports in literature indicate a possibility of association between risk of increase in lifestyle-disease-incidences and the acquisition of clinical vulnerability (ACV) in subjects chronically exposed to pollutants. Occurrence of oxidative stress is known to be the first and foremost change for the onset of NCDs. Therefore a periodic assessment of imbalance in levels of oxidants and antioxidants is plausible that can be performed by determining levels of cellular oxidative damage and the Total Antioxidant Capacity (TAC) in blood or body fluids. Elucidation of subnormal TAC can provide an opportunity for protection from ACV or getting predisposed to diseases and disorders through evidence based timely supplementation of antioxidants. In this review, we hypothesize, and appraise, the utility and significance of TAC measurements as a public health tool for monitoring ACV. Its measurement at different levels of NCD prevention shall result in efficient implementation of global action program for control of NCDs burden. Points in approval are ease, reliability, specificity, reproducibility, and the inexpensiveness of the method. We also contend that further research could lead to development of a proper cocktail of antioxidants to be used as adjuvant therapeutic measures to delay or reverse existing NCDs and their impact in individuals. We propose TAC as an early indicator that can be used to detect and control ACV and related NCDs.