The industrial revolution 4.0 with its rapid development speed and far-reaching impacts on the development of each country, if being left behind of this revolution, the lags behind the development is also inevitable. On the contrary, if making good use of the advantages of this revolution, the opportunities are huge. Industry 4.0 is based on people, in which high-quality human resources are the core for development. This is also the development direction that each country needs to prepare for incessant changes in the future. This article will present the issue of "Vietnam's higher education in the era of Industrial Revolution 4.0: Opportunities, challenges, and innovations”