Objective: Pseudomonas aeruginosa is an important cause of hospital acquired infection especially in patients admitted in critical care units such as intensive care units and burn care units. In recent times, it has emerged as a widespread Multi Drug Resistant (MDR) pathogen which requires antibiotic susceptibility testing on a regular as well as a periodic basis. This study was carried with an aim to determine the antimicrobial resistance pattern and prevalence of MDR P. aeruginosa infection among burns patients at a tertiary care centre. Material and Methods: This retrospective study of pus samples of hospitalized patients in burn wards between January 2018 to June 2018 was carried out. The intensity of use of antibacterial agents and resistance of P. aeruginosa to common anti-Gram-negative antibiotics were measured. The antibiotic sensitivity testing of all P. aeruginosa isolates was done using Kirby-Bauer disc diffusion method and the results were interpreted according to the Clinical and Laboratory Standards Institute guidelines (CLSI) 2017. Results: Out of these 130 clinical specimens, Pseudomonas aeruginosa was isolated in 38(29.2%) samples. P.aeruginosa showed maximum sensitivity to Imipenem (90%), Piperacillin-tazobactum (78%) and Gatifloxacin (52.6%) followed by Tobramycin (28.9%), Ciprofloxacin (23.6%) and Gentamycin (13.1%). Conclusion: Pseudomonas was the commonest cause of infection in fire burn patients in our setting. About 29.2% of the isolates showed multiple resistances. In light of our findings, regular antibiotic resistance test has to be done for each patient in order to select an appropriate antimicrobial agent.