Abstract: The objective of the study was to evaluate the phytochemical and in-vivo antihyperlipidemic activity of Solanum spirale Roxb. leaves. The physiochemical standardization of the dried leaves powder was done with respect to ash values, foaming index, extractive values and moisture content. The dried leaves were extracted with petroleum ether, chloroform and water. The phytochemical analyses were carried out and the antihyperlipidemic activity of the chloroform and aqueous extracts were evaluated. The antihyperlipidemic study was carried out by inducing hyperlipidemia in rats by means of triton. The serum collected was analyzed for total cholesterol, triglyceride, low density lipoprotein, and high density lipoprotein. The result of the present study revealed that both the aqueous and chloroform extracts of leaves of Solanum spirale Roxb. possess antihyperlipidemic activity.