The introduction of nanotechnology into our world has ushered in a slew of changes and provided a wealth of knowledge that has fuelled progress in many sectors of existence. Recent advances in nanotechnology have shown the importance of metal oxide nanoparticles due to their potentials in different sectors, particularly in nanomedicine and related biomedical fields. Metal oxide nanoparticles (MOx-NPs) such as titanium dioxide nanoparticles (TiO2-NPs), copper oxide, silicon dioxide, zinc oxide and Iron oxide have gained a lot of prominence as a result of their unique properties. Metal and MOx-NPs based nanoparticles are being employed to create a novel antibacterial drug formulation, which is a revolutionary and ground breaking method to drug discovery and development. Different methods are employed for the synthesis of these nanoparticles of which green synthesis is found to be a better option. It involves the use of plant extracts which is a non-toxic solvent. Green materials offer a variety of advantages, such as low energy consumption and the capacity to operate under moderate operating conditions (such as pressure and high temperature) without the use of harmful chemicals or catalysts. Therefore, more research efforts should be geared toward the advancement of this important technology.