Salinity is one of the major abiotic stress factors in plants that devastatingly affect the plants growth and reduce productivity. The major causes of soil salinity are dry climates and low precipitations, high evaporation rate, which adds salts to the ground surface; poor drainage or waterlogging. Tracking the genetic sequences and control of switching on/off of such transcriptional genes may help in mitigating influences of several biotic and abiotic stresses. PtSOS2, AtNHX1, and OsRab7 are the most important salt tolerant genes. Under drought treatments, induction of NAC and homeobox domain containing TFs illustrates their regulatory roles. Uptake of compatible solutes, synthesis of antifreeze proteins and antioxidants, and expression of cold responsive genes perform significant preventive roles against cold stress. Glucanase gene is one of the reflective examples of disease resistant enzyme. It catalyzes the synthesis of phytoalexins. Through this is strategy, the process involved in defensive mechanisms of plants contouring abiotic stress. Heat shock (HS) is often lethal to plants and exert negative impacts on the structural as well as functional profiles in many crops. It occurs by genetic modification in the Arabidopsis by viral DNA from recognition by the guide RNA.