Objective: To study the clinicopathological features of xanthogranulomatous inflammation in various organs. Materials and methods: A retrospective 5 years clinico-pathological study of all xanthogranulomatous inflammatory lesions observed at our Institution from 2014 to 2018 was carried out. The clinical parameters and histopathological features were documented with review of literature. Results: Total number of xanthogranulomatous inflammatory lesions encountered in this study were 31 with maximum incidence among 41-50 years age group and Female: Male ratio of 2.1:1. Around 38.7% of cases occurred in the female genital tract. Associated findings include suppuration, necrosis & hemorrhage, actinomycosis, maduramycosis, suture material, endometriosis, calculi and filariasis in this study. Conclusion: Xanthogranulomatous inflammation that mimics malignancy clinically is being increasingly encountered in various organs thereby warranting careful histopathological examination for guiding proper treatment.