Background: Conscious sedation is a guidance technique used to control the behavior of anxious or uncooperative patients. A variety of drugs are used in the sedation process, including inhalation agents such as orally or parenterally midazolam and other benzodiazepines. Midazolam is considered a member of the benzodiazepine family with the highest lipid-soluble properties. Objective: This article aims to review the use of Midazolam for conscious sedation in dental practice and illustrate each route of administration. Materials and Methods: This study involved a review of published articles related to the use of Midazolam for conscious sedation in dental practice. The PubMed search engine and Cochrane electronic databases were used to collect the most relevant and recent information on midazolam in dental practice. Results: By applying this method, 10 articles were gathered and used in the current review. Conclusion: Midazolam has shown its ability to be a safe and effective drug in conscious sedation in dental practice. However, some points must be considered before administering midazolam, including patient age and weight, the dose required, drug-drug interaction, special care patients, route of administration, and level of anxiety.