Background: Traumatic brain injury is defined as an alteration in brain function caused by an external force; it is responsible for high mortality around the world. Hyperglycemia aggravates underlying brain damage and influences both morbidity and mortality in critically ill patients. Aim: The aim of our study is to examine the relationship between blood glucose and outcome after traumatic brain injury in Sudanese Patients. Methods: This is a cross-sectional study conducted at the National Center for Neurological Sciences from October 2015 to October 2018; blood specimens were obtained from 210 TBI patients and processed for plasma glucose measurement. Results: Two hundred and ten patients with TBI were enrolled in the study, 91.0% were males and 9.0% were females. The most affected age group ranged between 19-34 years in 75 patients. The present study revealed that normoglycemia (Glucose level 70-180 mg/dl) was detected in 79.0%of patients, while dysglycemia was detected in 21% of patients. Moreover, in this study, regarding the outcome and blood glucose, among dysglycemic patients (44), 61.1% of the hypoglycemic patients were found with mild disability according to GOS classification, while 66.6% of the hyperglycemic patients died. Conclusion: This study demonstrated a significant difference in blood glucose levels among patients with TBI.