Saudi Journal of Pathology and Microbiology (SJPM)
Volume-4 | Issue-02 | 99-106
Original Research Article
Endometrial Findings in Abnormal Uterine Bleeding
Dr. K. Kasthuri Thilagam, Dr. M. Thenmozhi
Published : Feb. 28, 2019
Abstract
Background: Alteration in the hormone status either due to primary intrinsic ovarian abnormalities or secondary
disturbances in the hypothalamo - Pituitary - ovarian axis results in AUB. The etiology of AUB is often related to
anovulatory disturbances and ovulatory disturbances. However, there is a need to evaluate the endometrial changes
specific for ovulatory and anovulatory causes of AUB at the histological level. This study was carried out to evaluate the
histomorphological pattern of endometrium in Abnormal Uterine Bleeding. Methods: This cross sectional study was
carried out among 100 women who were diagnosed with AUB in our tertiary care hospital between 2012 and 2014.
Endometrial biopsy sample was taken on the third week of menstrual cycle. The samples received were carefully
examined for the presence of mucus & large blood clots, and, if found were removed. One slide stained
with conventional Haematoxylin & Eosin, second slide with Per iodic acid Schiff method and third slide was stained with
Gomeri's method for reticulin stain. Results: A total of 100 cases were analyzed in this study and majority of the cases
consisted of anovulatory disturbances (62%) followed by ovulatory disturbances (34%). While majority of the
anovulatory cases were irregular proliferation (27%), majority of the ovulatory cases were deficient secretory state with
co-ordinated delay (11%). Conclusion: In the modern era of minimally invasive surgical and diagnostic procedures, there
is a growing need for the histopathologist to develop acumen for diagnosis of AUB. This study has extensively
highlighted the variations in the endometrial presentation for an in depth analysis of AUB.