Background to the study: The use of insecticides have been encouraged in most Nigerian homes in the eradication of insects that could harm humans despite the side effects of exposure to these insecticides. The study aim was to examine the toxic effect of inhaled dichlorvos (DDVP) on the histological architecture of the testes of wistar rats on short-term exposure. Methods: Twenty (20) albino male wistar rats weighing 140g – 180g were recruited for this research and were randomly placed into four (4) groups of five (5) rats per group. Group 1 was control group, while groups 2 – 4 were given 10ml DDVP/90 ml distilled water – v/v, 20ml DDVP/80 ml distilled water – v/v and 40ml DDVP/60 ml distilled water – v/v, respectively. At completion of exposure, rats were anaesthetized with chloroform, sacrificed and their testes were harvested for routine histopathology procedure. The stained sections were morphologically evaluated and the pictures of the slides compared. Photomicrographs were obtained with the aid of Am-scope camera fitted on an Açu-scope microscope. Results: Results obtained from the control group showed that the testes presented with a normal histological make-up depicted by the presence of normal seminiferous tubules, no signs of germ cell distortions. However, experimental groups showed graded levels of degenerative changes in germinal layers of the seminiferous tubules as well as notable vacuolations. Conclusion: It can be concluded that prolonged exposure to dichlorvos inhalation could be toxic to the reproductive system of male wistar rats.