Plasma lipid can be affected by variety of ways in patient‘s of liver disease. Liver cirrhosis is associated with reduction in plasma TG and TC levels due to reduction in lipoprotein biosynthetic capacity. To study the lipid profile in patients of liver cirrhosis. One hundred and fifty subjects were studied after dividing them in to Case Group (n=75, patients with liver disease) and Control (n=75, age and sex matched apparently healthy subjects). Child Pugh Score (CPS) was used to assess the liver cirrhosis. MELD score was also estimated. Lipid profile was measured for all the subjects and correlated with different parameters. Mean age of cases and control group was 43.47±14.12 and 43.21±14.47 years respectively (p=0.914). Majority of the Cases and control were male (74.66%) and 77.30% respectively. TC and HDL level was low in subjects belong to CPS class C in comparison to subjects belong to CPS class B (p=0.03). Level of LDL, TG and VLDL were observed low in Cases which belongs to CPS class C in comparison to cases belong to CPS class B (p>0.05). Total serum protein and serum albumin was significantly low in Cases compared to Control (p=0.001) whereas serum globulin was significantly higher in Cases as compared to control cohort (p=0.001). Decrease in lipid level was noted in liver cirrhosis patients and severity of liver cirrhosis has lead to even more lower level of lipid in CPS class C compared to class B.