Red cell distribution width (RDW) is a measure of degree of variation in the red blood cell size. RDW is recorded as a part of the standard complete blood cell count. The objective of this prospective research study is to find out the independent association of RDW with morbidity in various clinical conditions. This was a fourteen months prospective study done on 450 patients who attended OPD in tertiary care hospital, out of which 306 patients were diagnosed with various clinical conditions, out of which 270 patients showed raised RDW values. In multivariable analysis, RDW remained significantly associated with patient morbidity. In patients, RDW is an independent predictor of morbidity. Considering the fact that RDW is routinely measured in complete blood count without added expenses, this can play role as an "priceless prognostic indicator" in patients.