Since the start of the coronavirus disease-19 (COVID-19) pandemic in late December 2019, in Wuhan, China, the severe acute respiratory syndrome coronavirus-2 (SARS CoV-2), the virus responsible for COVID-19 present with the classical presentation of respiratory as the name denote that may be fatal. However, there are reports of atypical manifestations in the majority of the patients. One of the atypical presentations is oral manifestations of SARS CoV-2 that may be due to the initial infection or reactivation of Herpes Simplex Virus-1 (HSV-1) or stress-related. Herein, we report a middle-aged man; who presents with vesicular lesions on the lip that were diagnosed clinically as herpes simplex labialis (cold sores), as confirmed by reverse transcription-polymerase chain reaction (rt-PCR) as SARS CoV-2 infected.