Pap smear is a screening procedure to detect precancerous lesions to prevent subsequent invasive cervical cancer. Manual Liquid Based Cytology (MLBC) has been developed as an alternative to Conventional Pap Smear (CPS) as it is said to increase the rate of detection of precancerous lesions as it reduces the screening time, the artefacts, giving a clean background on the smear. In this study, cervical screening was performed in all married women of reproductive age group who visited Department of Obstetrics and Gynaecology over a period of one year from February 2017 to January 2018. Out of which 350 cases were randomly selected for comparison between CPS and MLBC. Slides were examined for cytomorphological parameters. CPS showed higher percentage of inflammatory lesion 80% as compared to MLBC with 46.1%, Unsatisfactory smear in CPS was 10% and in MLBC was 49%, Normal smear was reported in 07% cases in CPS and 3.15% in MLBC. Most common cause of unsatisfactory smear in CPS is obscuration by blood and inflammation whereas that in MLBC was scant cellularity. The cellular features are better in MLBC as compared to CPS and also background is more clear in MLBC as there was no obscuration by RBCs or inflammatory cells while in CPS, the background is dirty due to the presence of RBCs, necrosis and inflammation