Medicinal plants are most valuable source of different natural compounds and safer than the chemicals that directly used for the treatment of high risk diseases. The compounds that present in the medicinal plants are monoterpenes, flavonoids, and phenolics. The ultimate goal of the using of medicinal herbs are inhibiting the growth of the infectious particles that causing variety of diseases. Medicinal plants have been used in order to control the growth of infectious bacteria in as some of them deviling the resistance due to changing endearments for example, Enterococcus faecium and Klebsiella pneumonia. Many of the plant extracts such as N.sativa seeds have been used as natural booster for targeting the lethal pathogens and causing the cellular toxicities While, Commelina africana L and Elephantorrhiza elephantine that binds with living cells by damaging’s the membranes of the toxic pathogens. The production of the free radicals due to stress or any environmental conditions may increase the risk of damage to DNA molecules. These free radicals binds to the double binds of the DNA molecule inhibit their functions in order to replicate for further central dogma processing. It give rise the production of peroxyl radicals species due to consecutive attack to the DNA molecule.