Gallbladder is affected by a wide spectrum of diseases ranging from nonneoplastic lesions like congenital anomalies, gallstones and its complications, noninflammatory, inflammatory, to the neoplastic lesions .The aim of the study spectrum of histopathological changes in cholecystitis. The objectives were to study the histomorphology and frequency of various gall bladder diseases among specimens received and to correlate the various types of mucosal responses to different gallstone characteristic (like type, number, size volume and weight). Gall bladder specimen after cholecystectomy of patients who was admitted in ward surgery of BPS GMC, Khanpur Kalan, Sonepat.Place of study:-Department of Pathology, BPS GMC Khanpur Kalan, Sonipat. Study design- Prospective study. Out of 339 cases, two hundred and ninety seven (87.61%) patients studied were females, whereas 42 (12.39%) cases were males. Male to female ratio was 1:7.07. Out of the 339 cases, 234 (69.7%) had mixed stones, followed by pigment 44(13%) cases and cholesterol31 (9.1%) and 27 (8.1%) had no stones. 126 (37%) had single stone, nine had (3%) double and the remaining 195 (58%) had multiple stones. Conclusion: The histopathological spectrum of gallbladder lesions includes chronic cholecystitis and associated mucosal alterations and lesions like metaplasia, dysplasia and carcinoma. Variants of chronic cholecystitis such as xanthogranulomatous, granulomatous and follicular cholecystitis were also noted. To conclude, it was seen that the average weight, volume and size of the gall bladder significantly correlated in increasing order with cholecystitis, hyperplasia, metaplasia and carcinoma.