Abstract: Type 2 diabetes mellitus has become a leading cause of morbidity and mortality world over. Insulin resistance plays a key role in the development of diabetic dyslipidemia, plasma lipid abnormalities contributes to the risk for atherosclerosis and coronary heart diseases in majority of patients with type 2 diabetes. The aim of the study was to assess the serum lipid profile in type 2 DM patients without and with complications. The current study was undertaken in 90 subjects. 30 diabetics without complications (group I), 30 diabetics with complications (group II) and 30 non diabetics as normal control group (Group III). The serum total Cholesterol, Triglycerides, LDL-C and VLDL-C levels were significantly much higher in diabetic cases with complications compared to cases without complications and HDL-C levels were significantly lower in cases of both the 3groups when compared to controls. The elevation of serum total Cholesterol, Triglycerides, LDL-C and VLDL-C levels were significant in both the study groups when compared to controls. We found significantly lower levels of HDL-C in diabetic cases with complications when compared to cases without complications. The lowering is significant in both the study groups when compared to control. Hence it is concluded that the serum lipid profile levels appears to be useful to prevent the diabetic complications and provide valuable information for proper medical intervention.