Beta thalassemia is one among the commonest hereditary haemolytic disorders that result from defective synthesis of haemoglobin and ineffective erythropoiesis. Very less data is available in the early identification of renal involvement in patients with thalassemia. Renal impairement in thalassemic patients may be due to chronic anemia, chronic hypoxia, iron overload and iron chelators toxicity. The objective of the study was to estimate renal parameters in pediatric age group with transfusion dependent beta thalassemia major and to correlate the outcome with the degree of iron overload. The study consists of 30 diagnosed cases of beta thalassemia major aged between 3-18 yrs admitted in Vani Vilas Hospital attached to BMC&RI, Bangalore and 30 healthy age and sex matched controls. Blood samples were analyzed for hemoglobin, serum urea, creatinine and spot urine sample for microalbumin. Data analysis was done by Pearson’s Correlation analysis and Student’s t test. Mean age of cases was 8.9 years (SD=4.14) among whom 50% were females and 50% were males. Mean age of controls was 9.06 years (SD=3.5). Mean hemoglobin levels were decreased significantly (p<0.01) in cases when compared to controls. Mean urinary microalbumin excretion was significantly increased (p<0.01) in cases as compared to controls and positively correlated with duration of chelation, suggesting renal damage. Therefore microalbuminuria is important to assess the risk of renal dysfunction in these patients.