Background: Stress is a negative emotional, cognitive, behavioral and physiological process occurs as individual adjusts with stressors. Due to the secretion of this cortisol and epinephrine blood vessels are tightenedas a result heart rate and blood pressure increases. Present study aimed to asses the level of perceived stress and its association with Pre hypertension in health professional beginners. Material and Methods: A cross sectional study was conducted in the Department of Biochemistry, SBKS MI & RC, SVDU for consecutive two batches 2016-17 & 2017-18. Total 506 first year MBBS, BDS & BPT students were studied for age, gender and Blood Pressure. Stress was assessed by PSS-10 scale. Two groups were identified as their PSS score, stressed and non-stressed. Results: PSS score showed that among all participants 71.74% (N=363) students were stressed and 28.26% (N=143) students were none stressed. In the present study the mean systolic blood pressure and diastolic blood pressure of 506 health professionals was 125.63±3.35 and 76.96±5.65 respectively which falls under the category of pre hypertension. Conclusion: Majority of students could be categorized as pre-hypertensive group based on blood pressure.An effective inclusion and implementation of regular exercise, sports and cultural activities and stress management program like meditation, yoga in the medical curriculum may be a key to reducing and or preventing stress-induced psychological distress and Hyperteinsion