To integrate with the jawbone and gum tissues, a prosthetic dental material must be appealing, long-lasting, repairable, cleanable, and bio-compatible. In terms of new prosthetic materials, prosthodontics is rapidly evolving. Despite the fact that all artificial materials emit compounds into the oral environment, side effects and unpleasant responses are possible. We utilized Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) to conduct an automated and manual search to find clinical studies that looked at the relationship between prosthetic materials and biohazards. A 'ideal' material will have properties that are equal to or very close to those of the material being replaced. One of the most important properties for any material used in the human body is biocompatibility, or more specifically bioactivity. Unlike other implanted materials, the biocompatibility of dental materials varies depending on their structure and state.