Immunity in insects is the series of events by discretion of signal proteins as a part of memory cells. The most important role of defensive proteins and peptides in insects are against function, assigning immune responses distinctly to priming and basal. But insects are also a source of high quality protein, containing many essential amino acids required for human nutrition. One their host enters into the cells of targeting area, immediate onset of proteolytic cascades that causes the cleavage of protein molecules of the attacking organisms. Immune system of the insects enhances exhibit properties the of production of antibodies and phagocytic cells to clear microbes and damaged cells from an organism. The most different types of immunological responses arise as pathogens enter into the cells of insects and activate the machinery of metabolic pools. The main reason for genetic and biochemical evaluation lie behinds the diversity of natural ecosystem of insects. Sterile insect technique has been controlled for direct killing. It is used primarily to control or eradicate insect pests, usually crop pests or human and animal. Integrated pest management, the broad-based approach that integrates practices for economic control of pests that significantly improved the yields of agricultural crops.