This study entails the research data of the empirical study carried out on the compressive strength determination of Granite dust-Sandcrete with granite dust as partial replacement of three (3) grades of river sand with fineness modulus (fm) of 2.29, 2.44 and 2.89. The percentage replacements range from 0%, 10%, 20%, 30%, 40%, 50% to 100%. A gross number of 102 cubes of 150 × 150 × 150mm square metallic mould were blend, mixed and cast with a mix ratio of 1:5. Three (3) cubes were blend, mixed and cast for each percentage partial replacement and a total 34 cubes for each grade of river sand, were crushed to derive the compression strength of 28th day curing respectively. For river sand with fineness modulus of 2.29, the highest strength was recorded on 80% replacement, while the least strength was recorded on 0% replacement. For the same river sand, compressive strength increased from 0% to 80% and assumed a descending trend from 80% to 100%. For 2.44 fineness modulus, the highest strength was recorded on 80% replacement, while the least strength was recorded on 0% replacement. Also, for the same river sand, compressive strength increased from 0% to 80% and assumed a descending trend from 80% to 100%. For river sand of 2.89 fineness modulus, the highest strength was recorded on 70% replacement, while the least strength was recorded on 0% replacement. Also, compressive strength increased from 0% to 70% and assumed a descending trend from 70% to 100%. Generally, the compressive strength assumed an upward trend as the percentage replacement increases.