Bone is the host to many diseases. Diagnostic biopsies of bone lesions are generally done in two forms i.e. Percutaneous core needle biopsy or open surgical biopsy. Core needle biopsy is initial method of tissue diagnosis in bone tumours. To study the adequacy and accuracy of core needle biopsy in diagnosing bone lesions. To establish definitive diagnosis of bone pathology. The study was conducted in department of pathology, MNJ Cancer Institute and TB & Chest hospital, Osmania Medical College, Hyderabad. A total of 53 cases were analyzed prospectively for a period of two years from October 2015 to September 2017. Female to Male ratio was 1.1:1, Average age 3 to 70 years. Out of 53, 26 cases were primary malignant bone tumors, 12 were metastatic deposits, 10 were benign tumours (9 -Giant cell tumors,1- osteo chondroma) 2 were chronic osteomyelitis,3 were not adequate. In 26 cases of primary malignant tumours 10 - osteosarcoma, 6 - ewings sarcoma, 4 - chondrosarcoma, 2 - plasma cell neoplasm, 1 case was high grade NHL, 1 - chordoma, 1 synovial sarcoma,1 germ cell tumour. Adequacy rate (94.6%) in our study is in concordance with the similar study of Amit Joshi et al., (2013) where adequacy rate was 92%.present study is also in concordance with study of Logon et al with adequacy rate of 97.8%. It has demonstrated that the Core needle biopsy is a safe, easy, and effective technique for the evaluation bone tumours, with a high rate of diagnostic yield and accuracy.