Introduction: A woman’s healthy state influences people around her with implication for the larger society. A woman’s quality of life is of importance to enhance fulfilment of responsibilities associated with her various roles. Therefore, the study examined the health seeking behaviour, described the health related quality of life and determined the relationship that exists between the health seeking behaviour and health related quality of life of female traders. Methodology: Cross sectional research design was adopted to gather data from six hundred female traders systematically selected in the largest open market in Ile-Ife, Nigeria. A questionnaire was utilized for data gathering. Institutional review board approval was obtained for the study. Results: Findings from the study showed that 65.3% of respondents had poor health seeking behaviour (HSB) and 54% had good health related quality of life (HRQOL) among this category of women. The result also showed a positive statistically significant relationship (r = 0.10, p <0.05) between health seeking behaviour and health related quality of life of female traders. Discussion: Among female market traders; health seeking behaviour was positively correlated with their health related quality of life.