Background: Wound sepsis continues to be a bugbear of emergency abdominal surgery where the producer is often inevitably performed on infected tissue. Wound infection causes prolongation of convalesces, prolonged hospital stay, permanent disability, economic loss, production of dangerous focus of infection in the ward, ugly scar and it is intimately related to the fame of the surgeon. The aim of the study was to evaluate aetiopathological of surgical site wound infection after caesarean section. Methods: The study was conducted at the Sher-e-Bangla Medical College Hospital, Barisal, Bangladesh to evaluate the Aetiopathological of surgical site wound infection after caesarean section. A total of 100 cases were chosen by random sampling with different maternity units from September 2007 to August 2008. The results were statistically analyzed with Statistical Packages for Social Sciences (SPSS-24). Results: Serosanguineous and foul smelling wound discharge were present in 70% of the cases. Culture of wound discharge showed growth in 67% of the cases and the organisms responsible for most wound infections originated on the patient’s skin. Staphylococcus aureus was the organism most commonly isolated. Escherichia coli was found as the second most common organism, followed by Pseudomonas, klebsiella, pneumonia, actinobacter and proteus. Conclusions: Proper operative site skin preparation (e.g. with povidone iodine) which greatly contributes to reduction of wound infection. Personal cleanliness, smooth gentle handing of tissues, proper haemostasis are all-important. This is possible only by careful surgeons.