Introduction: Cancer is one of the leading causes of death worldwide and is also one of the major causes of morbidity in both developed and developing countries like India. In 2020, total number of new cases in India was 13, 24, 413 and number of deaths reported was 8, 51, 678. Number of cancer cases is on an increasing trend every year. As resources are very few in our country a well-developed cancer registry and statistics would help in identifying the risk factors for various cancers and thereby preventing their occurrence. Objectives: 1) To study the incidence of cancer cases in a tertiary care center with respect to organ system, site, age, gender and type of cancer. 2) To ascertain the leading cancers in a tertiary care hospital and compare the incidence with various other epidemiologic studies. Materials and methods: The present study is a Hospital based Retrospective study done from January 2019 to June 2021 for a period of two and half years in Department of pathology, Andhra medical college. A total of 1760 cases are studied during this period. Various demographic details like age and sex are collected along with site and clinical diagnosis for the study. Data was entered and analyzed using MS excel 2013 and pie charts and frequency graphs were plotted for easy analysis of the data. Results: Out of 1760 cancer patients’ females were 993(56.4%) and 767 were males (43.5%), larger number of the male patients with cancer were in the age group of 51 -60 years and females showed up in the age group of 45 to 55 years. In our study the most common tumors were tumors of Head and neck (oral cavity included) with 491cases (27.89%) followed by cervical cancers with 279 cases (15.8%). In males out of total 767 cases the most common cancer was oral cavity cancers (250cases/32.59%) followed by GIT cancers (140 cases/18.25%) and in females out of 993 cases the most common cancer was cervical cancer(279 cases/28.09%) followed by breast cancers(196 cases/19.73%). Conclusion: The present study emphasizes on burden of various cancers at the level of a tertiary care center. In recent years there is an increasing incidence of cancers in females.