Abstract: Pre-eclampsia, is an obstetric disorder characterized by hypertension and proteinuria that prevails all over the world. It presents as a pressing peril for fetal and maternal lives. Though inflammation, increased levels of TXA2, ischemic placenta, dysfunction of endothelium are discerned, the exact pathophysiology yet remains a mystery. The absolute treatment is still to be discovered, however its prevention by low dose aspirin and calcium supplementation present as promising preventative measures for pre-eclampsia. To observe the effect of aspirin and calcium in prevention of preeclampsia. This was a prospective clinical trial study for evaluation of role of aspirin and calcium in prevention of pre-eclampsia in primigravidas. It was carried out at department of Obstetrics and Gynecology at AL-Wahda hospital Derna from Jan 2016 to Dec 2016. Three hundred and forty four primigravidae were included in the study. Their age ranged from 16 to 45 years with a mean 26.32 ± 4.88 years. Out of the 344 healthy primigravidae, 63 (18.3 %) developed preeclampsia. Both (aspirin and calcium) supplementations were associated with a reduction preeclampsia. There was significant difference between the group taken both (aspirin & calcium) group and prevent pre-eclampsia (X2= 6.07, P= 0.014). In Conclusion, It was noted in the present study that low dose aspirin and calcium might have beneficial effect in the prevention of preeclampsia.