Kidney diseases rank 3rd amongst life threatening disease, after cancer and heart disease. Anemia is an constant complication of chronic kidney disease that significantly contributes to the symtoms and complications of the disease. Aim of the study is to study the hematological manifestations ofchronic kidney disease (CKD) and to correlate the hematological abnormality with the clinical stage.182 patients with chronic kidney disease admitted in Osmania general Hospital were included in the study for a period of 2 years. Patients in various stages of the disease were studied for various hematological parameters. CKD was seen across all age groups. Increased prevalence of CKD was seen in the age group of 41 - 50 years. Majority of patients at presentation were in stage V CKD. Hypertension (47.2%) was the leading cause of CKD, followed by diabetes. Ischemic heart disease was the most common associated illness seen in CKD. The mean hemoglobin in the present study was 7.99 +/- 1.2 g/dl. The fall in mean hemoglobin had an inverse correlation with the stage of CKD. The mean RBC count was 2.73 x1012/l, with significant fall in the RBC count as the stage of CKD progressed. The mean absolute reticulocyte count also showed significant decline as the stage progressed.Chronic kidney disease is seen across all age groups with a malepreponderance. Hypertension is the most common cause of CKD. The anemia of CKD is a normocytic normochromic anemia. The fall in hemoglobin is due to low RBC count due to decreased erythropoiesis.