Biosensors for virus and bacterial detection and control have been developed over the last thirty years as a result of various biotechnological breakthroughs. With the exception of avian species, cell-lines offers certain advantages and are accessible for domestic animals. Current diagnostics rely on ELISA or RT-PCR, whereas these procedures frequently have limitations in terms of speed and sensitivity. Amplification techniques of nucleic acid are extremely beneficial for detecting viruses which are difficult and dangerous to culture, viruses that develop slowly in culture, and viruses with antigenic variants such as HCV (hepatitis C virus), Zika virus, dengue virus, EBV, influenza viruses, HIV, Ebola virus and coronavirus. Pathogen isolation and characterization, RT-PCR and sequencing-analyses are common. LAMP (Loop mediated isothermal amplification) has evolved into an important alternative for simplifying infectious illness diagnosis. Diagnostic assays are employed to determine present, functional SARS-CoV-2 infections. Diagnostic techniques can be antigen based for specific proteins on the virus's surface, or molecular based like LAMP, CRISPR and PCR. The gold-standard for the testing of COVID-19 is RT-PCR, that identifies SARS-CoV-2 genetic-information in nasopharyngeal specimens.