Managing orbital floor injuries is often a multifaceted issue. Repair of these defects essentially aims to restore the continuity and stability of orbital floor providing an adequate support to the orbital contents. Several bio-materials and implants have been used over the years in the hope of achieving the best result. Traditionally autografts are considered to be the ‘gold standard’. In order to overcome the drawbacks of autografts, researchers’ and surgeons’ attention has been progressively attracted by alloplastic materials which are commercially produced and can be easily tailored to fit a wide range of clinical needs. In this review the advantages and limitations of the various biomaterials proposed and tested for orbital floor repair are critically assessed and discussed. A thorough electronic search was carried out in February 2018 for pertinent English language literature without any time restrictions. The inclusion criteria were prospective or retrospective studies including randomized or quasi-randomized controlled trials (RCTs), controlled clinical trials (CCTs), retrospective studies and review articles with the aim of evaluating biomaterials for orbital reconstruction.