Objective: The aim of the study is to determine the prevalence of hypertension and related factors among health-care employees in Najran, Saudi Arabia. Methods: A cross-sectional survey was done among health care professionals who work for the Ministry of Health's, Directorate of General Health Affairs in Najran, Saudi Arabia southern region. The study sample size was 200 and the data were collected through a self-administered questionnaire. Assessed the level of hypertension by checking blood pressure followed by determinants related to hypertension. Data were analyzed by using descriptive and inferential statistics. Results: The study's findings, the majority of medical staff (92%) and non-medical employees (88%) had pre-hypertension, and 88 (42%) medical and 80 (40%) non-medical staff had stage one hypertension, and 24 (12%) medical staff and 32 (16%) non-medical staff had stage two hypertension. BMI, junk food, family history of hypertension, smoking status, and physical activity all play a role in hypertension levels. Conclusion: The study's findings show that healthcare employees, regardless of their job description, suffer from a high rate of hypertension. Hypertension levels are strongly linked to determining factors such BMI, junk food, family history of hypertension, smoking status, and physical activity. Health-care professionals should have frequent medical checks, and effective health-promotion programs should be established to reduce the risk of hypertension and improve the health of health-care workers.