Introduction: Oroantral communication (OAC) is an iatrogenic complication that occurs most frequently after the extraction of maxillary posterior teeth. Various techniques have been described in literature for its closure. Nevertheless, regenerative medicine has emerged as a novel strategy utilizing bioactive materials such as Platelet-Rich Fibrin in management of oral and maxillofacial soft and hard tissue wounds including OAC. Case Report: The present report describes a closure of oroantral communication using PRF. The OAC occured after the extraction of the right first maxillary molar in a 68-year-old patient. After one month of follow up, the extraction site showed a good healing process without any local or sinusal complication. Conclusion: the closure of OAC using platelet-rich fibrin membrane is a less invasive procedure than buccal sliding flap or buccal fat-pad techniques. It keeps the vestibular sulcus depth. It is also autogeneous and contains growth factors, which helps to accelerate soft tissue repair.