The paper investigates the impact of the contribution of road infrastructure expenditure on economic growth of Benin Republic using Jarque-Berra, White test, Breusch-Godfrey, Cusum and Cusum of squares techniques for the period (1985-2015). Overall the results reveal that gross domestic product, gross capital formation, labor productivity and road infrastructure expenditure play an important role in economic growth in the Benin Republic. More importantly, the study finds that road infrastructure expenditure in the Benin Republic has a significant positive contribution to economic growth in the long run than the short run. It is the same result with the gross capital formation. The labor production has a significant positive contribution to economic growth in long run. On the basis of these results analysis, it is strongly suggested to formulate certain recommendations in the field of economic policy that improves the road infrastructure expenditure as well as gross capital formation for sustainable economic growth in the Benin Republic. A new model has been proposed to the General Directorate of Public Works in effectively monitoring the level of road infrastructure expenditure in terms of growth and poverty reduction objectives