Background: While the association between perceived stress and non odontogenic conditions are well document, little is known as regard association between odontogenic conditions and perceived stress. This study therefore aimed to assess determine relationship between odontogenic conditions and perceived stress among dental patients in the University of Benin Hospital, Nigeria. Materials and Methods: This was a descriptive cross sectional study on randomly selected samples of patients aged above 18years from April to September 2019. The data collected were age, gender, smoking habit, socioeconomic status, and the levels of stress perceived. The result of continuous data was presented as ranges and mean±SD while that of categorical data was presented as frequency and percentages. Descriptive and inferential statistics were done using SPSS Version 20. A P-Value less than 0.005 was taken as significant. Results: All the 79 respondents approached agreed to participate in the present study giving a response rate of 100%. The age ranged from 17 to 79 years with a mean age of 36.1±16.9 years. There were 50.6% males and 49.4% females. There was no patients that had high level of stress, however, over half of the patients (60.8%) perceived moderate level of stress. The mean PSS score for the study sample was 5.09±2.79, with a range of 0.00 - 10.0. In the univariate analysis, the age, gender, socioeconomic status, smoking habit, and dental conditions was observed not to be statistically significant with the PSS score (P > 0.05). Conclusion: Most patients that present with dental conditions in our study were moderately stressed with none seen to be highly stressed. The level of stress was not associated with age, gender, socio-economic status as well as the dental condition in the present study.