The study was conducted Kingdom of Saudi Arabia in 2019. This study aimed to assess knowledge, attitude and practice towards use of physical restraints among nurses those working acute In-patient care settings. Participants were Registered nurses who are working in tertiary care centre. Descriptive design was adopted; sample was selected through convenient sampling technique. The inclusion criteria for this study were Registered nurses working in inpatient non-critical areas total of 138 nurses were eligible. The final sample consisted of 125 nurses with 86% response, majorities were females (88.8%). 70% of the participants were between age of 31-40 years. Higher numbers had completed Bachelors in Nursing Bachelors in Nursing. 79% participant’s position as registered nurse III and 54.4% were shift in charge of their units. The mean score on knowledge scale was above average of 26.31 ± 2.60 that indicates good knowledge about use of restraints. Mean score on attitude was 30.57 ± 4.56 and suggest favourable attitudes among the participants towards use of physical restraints. The mean score of practices related to use of restraints was 35.36 ± 2.17. These findings indicate good practice related to use of physical restraints among nurses, with the median Knowledge Score Total being highest in Males. However, there was no significant difference between gender with attitude and practice of the nurses with related use of physical restraints. In relation to designation There was a significant association found between the 3 nurses’ groups in terms of Knowledge Score Total (χ2 = 6.990, p = 0.030), with the median Knowledge Score Total being highest in the Designation: Registered Nurse II group.