Patient satisfaction, which is linked to nursing care, is the cornerstone of good hospital services. As a result, this survey was designed to record inpatients' perceptions of nursing staff and use it as a foundation for future improvement. The current cross-sectional study was carried out in Najran General Hospital, Najran. Data was collected from 135 patients by using the Karen patient perception scale and analysis through statistically. The overall satisfaction level for nursing staff was being good among 56 (41%) and 68 (5%) felt satisfactory level of nursing care and 11 (8%) perceived as low level of nursing care quality. At the p 0.001 level, there was a significant relationship between patients' perceptions of nursing care quality and their age, sex, related illness, and number of hospitalizations. Although overall satisfaction was excellent, six patients expressed dissatisfaction with the atmosphere and one patient expressed dissatisfaction with the hospital's system. The authorities were alerted of the situation in order to take any necessary corrective measures. This was quite beneficial in terms of enhancing patient care.