Introduction: Vaginal discharge is one of the most common problems faced by women in reproductive ages. Most of the time it caused by bacteria, fungi or parasites and many times these infections are sexually transmitted. Aim of the study: The aim of this study is to observe the responses of improvement symptoms and to reduce the risk of complication. Methods: This randomized study was conducted in Department of Obstetrics and Gynaecology OPD in Shaheed M. Monsur Ali Medical College and Hospital. Two hundred and nineteen patients were selected with the complaints of vaginal discharge with or without urinary symptoms, pruritus vulvae and lower abdominal pain. Couple were given one day combination kit therapy, containing (Fluconazole 150 mg, Azithromycin 1 gm, Secnidazole 2 gm). They were called after two weeks to know about their outcome of treatment or persisting symptoms. Result: In the study population, 55% women had excellent response for vaginal discharge, 46.8% women had excellent response for urinary symptoms and 62.3% women had excellent response for pruritus vulvae. Most common adverse effects of kit therapy were anorexia 44.54%, metallic taste 32.77% and nausea 38.66%. Conclusion: This strategy has had a considerable impact in decreasing the burden of STD in society with high cure rate for vaginal discharge.