Saudi Journal of Pathology and Microbiology (SJPM)
Volume-3 | Issue-07 | 201-210
Original Research Article
Clinicopathological and Immunohistochemical Study of Synovial Sarcoma: A Series of 42 Cases from Single Institution
Deepthi B, Uppin SG, Challa S, Uppin MS, Paul TR, Prayaga AK
Published : July 30, 2018
Abstract
Synovial sarcoma is a translocation associated sarcoma characterized by
SS18 – SSX1/2 fusion. It is one of the common adult soft tissue sarcomas
predominantly affecting lower extremities. In resource poor settings, exact
characterization by molecular methods may not be feasible always. In our study we
attempted to study the clinical profile, histomorphology and immunoprofile of cases
diagnosed as synovial sarcomas. Forty two cases diagnosed as synovial sarcomas based
of presentation, histomorphology and immunopanel were analysed .The median age of
presentation was 26 years with male to female ratio of 1.5:1. Majority of the sarcomas
were of monophasic type (83%) with predominant hemangiopericytomatous pattern
(67%) followed by fascicular pattern (48%). Tumor size was greater in adults older than
20 years when compared to younger age group. Tumors with large areas of calcification
were seen with significantly low mitotic index.